Name: La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Price range: $91 total
Rating: 8.8

Photo by JG Morris

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Hilton Garden Inn Chesterfield

$240

per person

Dec 15 - Dec 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.2/10 Very Good! (767 reviews)

Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!

Reviewed on Oct 26, 2025

The Wildwood Hotel

Save 100% on your flight

$244

per person

Dec 15 - Dec 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,591 reviews)

Staff was super friendly and the facilities were fantastic!

Reviewed on Nov 6, 2025

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Grand Center

$283

per person

Dec 15 - Dec 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,013 reviews)

Very unique and clean, and friendly staff

Reviewed on Nov 3, 2025

The Knight Center at Washington University

$285

per person

Dec 15 - Dec 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.4/10 Exceptional! (416 reviews)

Great location and the room was perfect

Reviewed on Nov 2, 2025

The Cheshire

$300

per person

Dec 15 - Dec 18

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,008 reviews)

Our room was very nice. The staff were always willing to be helpful. Breakfast was amazing! With the added perk of Starbucks in a cosy, quaint coffeeshop as part of the Cheshire. Our stay was perfect.

Reviewed on Nov 4, 2025

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Discover the most popular places to visit in Southeast Missouri

Taum Sauk Mountain in located in the St.Francis mountain range of south/central Missouri. It's also the highest point in Missouri. My kids are standing at the spot where the actual marker sign in

Elephant Rocks State Park

5/5(13 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Beautiful area. Easy to get up close and not too far off the main road. 🏞 #waterfalls #nature #explore #missouri

Rocky Falls

4.5/5(2 reviews)

Commune with nature and explore the great outdoors at Rocky Falls during your travels in Winona. While you're in the area, wander around the natural setting.

Breathtaking view at the dam by the road and some small trails for walking as well!

Lake Wappapello

4/5(18 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive, Cape Girardeau, MO

Fully refundableReserve now, pay when you stay

$94 nightly

$106 total

Nov 14 - Nov 15

Total with taxes and fees

9.4/10 Exceptional! (1,000 reviews)

Beds were comfortable and good breakfast

Reviewed on Oct 28, 2025

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St, Farmington, MO

Fully refundableReserve now, pay when you stay

$54 nightly

$62 total

Nov 13 - Nov 14

Total with taxes and fees

8/10 Very Good! (1,007 reviews)

The room was clean and the staff, as always were very courteous!

Reviewed on Nov 3, 2025

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3003 SOUTH OLD ORCHARD ROAD, Jackson, MO

Fully refundableReserve now, pay when you stay

$84 nightly

$91 total

Nov 10 - Nov 11

Total with taxes and fees

8.8/10 Excellent! (647 reviews)

Room was clean and check in was quick and efficient.

Reviewed on Nov 5, 2025

See all 602 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.