Southeast Missouri Vacation Packages 2026 from $197

Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Riverport

Save 100% on your flight

$197

per person

Nov 6 - Nov 9

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

7.6/10 Good! (1,012 reviews)

Breakfast was a laugh. Toast and microwave oatmeal, lol. At least there was coffee.

Reviewed on Sep 22, 2026

The Wildwood Hotel

$402

per person

Nov 6 - Nov 9

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.2/10 Wonderful! (1,657 reviews)

Very nice hotel. Only concern is the single elevator, since the front desk is on a different level than the bulk of the rooms. Makes for congestion in the morning when housecleaning staff are using it.

Reviewed on Sep 23, 2026

The Cheshire

Save 100% on your flight

$387

per person

Nov 6 - Nov 9

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,004 reviews)

The Knight Center at Washington University

Save 100% on your flight

$310

per person

Nov 6 - Nov 9

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.4/10 Exceptional! (668 reviews)

Very nice. Excellent location

Reviewed on Sep 22, 2026

Ameristar Casino Resort and Spa

Save 100% on your flight

$399

per person

Nov 6 - Nov 9

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,033 reviews)

Great, friendly staff. The rooms are clean and it is easy to park.

Reviewed on Sep 22, 2026

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A sunset over a lake with boats and ducks.

Lake Wappapello

8.8/10 (54 reviews)

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

96% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Sep 28 - Sep 29

Total with taxes and fees

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$72 nightly

$81 total

Sep 28 - Sep 29

Total with taxes and fees

9.2/10 Wonderful! (1,000 reviews)

"I was looking for something that was good quality and wouldn’t break my wallet. This place was what I was expecting. Lady working the breakfast was extremely polite and helpful."

Reviewed on Sep 20, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$63 total

Oct 11 - Oct 12

Total with taxes and fees

8/10 Very Good! (1,001 reviews)

"This older property is a good value for a one-night stay, but don't expect to be blown-away. No elevator to the 2nd floor, nice TV channel guide (in room), but couldn't access the listed channels (and they couldn't get that addressed while we were there), fairly minimal breakfast. But clean, roomy ..."

Reviewed on Sep 22, 2026

See all 691 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.