Southeast Missouri Vacation Packages 2026 from $252

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$252

per person

Oct 13 - Oct 16

found 1 day ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

9.2/10 Wonderful! (1,672 reviews)

This place is great and so are the staff. I would not expect a place this nice to allow pets.

Reviewed on Aug 8, 2026

Remodeled and Inviting Free EV

Save 100% on your flight

$551

per person

Sep 27 - Oct 2

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

10/10 Exceptional! (1 review)

It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

The Cheshire

Save 100% on your flight

$403

per person

Sep 24 - Sep 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.8/10 Excellent! (1,005 reviews)

Residence Inn by Marriott St Louis Downtown

Midtown

Save 100% on your flight

$349

per person

Sep 24 - Sep 28

found 1 day ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

7.8/10 Good! (1,002 reviews)

1) Put a number of towels based on the amounth of people in the room. 2) Insert something to put clothes during shower.

Reviewed on Aug 6, 2026

The Knight Center at Washington University

Save 100% on your flight

$323

per person

Oct 13 - Oct 16

found 1 day ago

Roundtrip flight included

Denver (DEN) to St. Louis (STL)

9.4/10 Exceptional! (646 reviews)

The hotel is a hidden gem. It is clean very secure and just a relaxing experience. Don’t forget to go into their pub which has great service and food. I would highly recommend this hotel.

Reviewed on Aug 8, 2026

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Stay near popular Southeast Missouri attractions

A large, reddish-brown rock formation with a smooth, rounded surface and a unique, intertwined shape.

Elephant Rocks State Park

9.6/10 (98 reviews)

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

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A large, historic building with a dome and columns, surrounded by well-maintained lawns and trees.

Southeast Missouri State University

8.8/10 (248 reviews)

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

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A waterfall, a river, and a red building in a forested area.

Current River State Park

9.2/10 (20 reviews)

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

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Century Casino & Hotel Cape Girardeau

8.4/10 (176 reviews)

Why not roll the dice with a visit to Century Casino & Hotel Cape Girardeau during your travels in Cape Girardeau? While in this family-friendly area, you can savor the top-notch restaurants.

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Century Casino Caruthersville

7.0/10 (57 reviews)

Why not roll the dice with a visit to Century Casino Caruthersville during your travels in Caruthersville? While in this family-friendly area, you can enjoy the restaurants.

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What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

96% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Aug 16 - Aug 17

Total with taxes and fees

9.6/10 Exceptional! (1,014 reviews)

"Friendly staff, clean room. Great food. Highly recommend this hotel."

Reviewed on Aug 9, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$57 nightly

$62 total

Aug 16 - Aug 17

Total with taxes and fees

The Riverview

777 Main St Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$107 nightly

$120 total

Aug 10 - Aug 11

Total with taxes and fees

9.4/10 Exceptional! (639 reviews)

"No water pressure in the shower, the shower floor was very slippery"

Reviewed on Aug 8, 2026

See all 678 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.