Name: Drury Inn & Suites Sikeston, MO
Price range: $128 total
Rating: 9.6

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

White House at Grand Central

Grand Center

Save 100% on your flight

$235

per person

Jun 22 - Jun 26

found 5 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.4/10 Very Good! (131 reviews)

Very clean and very friendly people

Reviewed on Nov 11, 2025

DoubleTree by Hilton Hotel St. Louis - Chesterfield

Save 100% on your flight

$569

per person

Jun 22 - Jun 26

found 5 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

8.6/10 Excellent! (1,003 reviews)

Not as good as it once was, but good enough once for a good price! Hilton Cookies and Decent Breakfast. Nice Staff. Quiet Location.

Reviewed on May 4, 2026

The Cheshire

$645

per person

Jul 15 - Jul 20

found 1 day ago

Roundtrip non-stop flight included

Los Angeles (LAX) to St. Louis (STL)

8.6/10 Excellent! (1,007 reviews)

The overall upkeep and cleanliness is not great. The breakfast bar was ok but not as well stocked or organized as it used to be and the eggs were always cold. I stayed 4 nights.

Reviewed on May 10, 2026

Ameristar Casino Resort and Spa

$754

per person

Jul 24 - Jul 29

found 22 hours ago

Roundtrip non-stop flight included

Newark Liberty Intl. Airport (EWR) to St. Louis (STL)

8.6/10 Excellent! (1,005 reviews)

The room was very nice and one of the cleanest hotel rooms I’ve stayed in. Very friendly staff and beautiful grounds

Reviewed on May 6, 2026

The Knight Center at Washington University

$239

per person

Jun 19 - Jun 21

found 4 hours ago

Roundtrip flight included

Atlanta (ATL) to St. Louis (STL)

9.4/10 Exceptional! (534 reviews)

Updated and clean room, thoughtfully designed. Friendly staff and walkable on a beautiful and safe college campus. Dinner at the restaurant on site was very pleasant as well

Reviewed on May 9, 2026

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Discover the most popular places to visit in Southeast Missouri

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

Ozark Craft Beverage - Brewery Tour

$155

per adult

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

May 17 - May 18

Total with taxes and fees

9.6/10 Exceptional! (1,009 reviews)

Room was clean and we had a good stay. Enjoyed complimentary breakfast and dinner. Overall would recommend.

Reviewed on May 9, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$63 total

Jun 2 - Jun 3

Total with taxes and fees

8/10 Very Good! (1,011 reviews)

Great Job!

Reviewed on May 8, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$111 nightly

$128 total

May 15 - May 16

Total with taxes and fees

9.6/10 Exceptional! (1,013 reviews)

Breakfast was good

Reviewed on May 9, 2026

See all 656 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.