Name: Drury Inn & Suites Sikeston, MO
Price range: $128 total
Rating: 9.6

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Your Southeast Missouri Vacation

Book a vacation package to Southeast Missouri and travel on your own terms. You'll be captivated by its family-friendly attractions, history and culture. Kick off your trip to Southeast Missouri with a few nights in Cape Girardeau visiting popular sights like Isle Casino Cape Girardeau and Cape Splash Family Aquatic Center. Sikeston is another city that lures travelers from all over. The Book Bug and Central Park are two of the leading places to see here. Expedia has hotels, flights, car rentals and more to help you curate your very own tailored Southeast Missouri vacation today.

The Latest Southeast Missouri vacation packages

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

$425

per person

Jul 28 - Jul 31

found 1 day ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

9.2/10 Wonderful! (1,667 reviews)

I absolutely love the wildwood. Best place to stay near St Louis. I will be staying with them again.

Reviewed on Jun 21, 2026

Remodeled and Inviting Free EV

Save 100% on your flight

$580

per person

Aug 7 - Aug 10

found 20 hours ago

Roundtrip flight included

Phoenix (PHX) to St. Louis (STL)

No reviews

Camden on the Lake Resort & Spa

$669

per person

Aug 6 - Aug 9

found 10 hours ago

Roundtrip flight included

New York (NYC) to St. Louis (STL)

9.2/10 Wonderful! (1,009 reviews)

Clean rooms great staff lots of amenities great gym

Reviewed on Jun 23, 2026

Moonrise Hotel

Delmar Loop

$436

per person

Sep 4 - Sep 6

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

9/10 Wonderful! (1,981 reviews)

Front desk staff were so very welcoming and helpful. They started our stay off well after a long day of travel. The room was clean and comfortable.

Reviewed on Jun 23, 2026

Hilton Pennywell St. Louis at the Arch

Downtown St. Louis

$534

per person

Sep 9 - Sep 12

found 1 day ago

Roundtrip flight included

Dallas (DFW) to St. Louis (STL)

8.8/10 Excellent! (1,088 reviews)

Close to many tourist attractions. Parking garage secure and safe. The front desk personnel were quite helpful and friendly. Would stay at this hotel again.

Reviewed on Jun 21, 2026

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Discover the most popular places to visit in Southeast Missouri

Elephant Rocks State Park

You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.

Current River State Park

Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.

Southeast Missouri State University

Take a campus tour or just explore the area of Southeast Missouri State University, during your trip to Cape Girardeau. While in this family-friendly area, you can savor the top-notch restaurants.

What to do in Southeast Missouri

Night Ghost Tour of Pythian Castle in Springfield Missouri

$20

per adult

100% of travellers recommend

See all activities in Southeast Missouri

Southeast Missouri Hotel Deals

Drury Plaza Hotel Cape Girardeau Conference Center

3351 Percy Drive Cape Girardeau MO

Fully refundableReserve now, pay when you stay

$100 nightly

$113 total

Jun 29 - Jun 30

Total with taxes and fees

9.6/10 Exceptional! (1,003 reviews)

"Excellent hotel clean, breakfast was awesome indoor pool awesome…. Excellent choice for hotel stay."

Reviewed on Jun 24, 2026

Baymont Inn and Suites by Wyndham Farmington, MO

1625 W Columbia St Farmington MO

Fully refundableReserve now, pay when you stay

$58 nightly

$64 total

Jul 12 - Jul 13

Total with taxes and fees

8/10 Very Good! (1,002 reviews)

"everything was as it shoiuldbe"

Reviewed on Jun 24, 2026

Drury Inn & Suites Sikeston, MO

2608 East Malone Ave, Miner Sikeston MO

Fully refundableReserve now, pay when you stay

$111 nightly

$128 total

Jul 1 - Jul 2

Total with taxes and fees

9.6/10 Exceptional! (1,001 reviews)

"This was a wonderful stay for the night while traveling. Thankful for the recommendation from the front desk to eat at Lamberts restaurant 3 minutes down the road. So fun!"

Reviewed on Jun 15, 2026

See all 664 properties in Southeast Missouri

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.